I find that the more “in” an in-joke is, the funnier and more durable it is. I recently made this re-skin of the Love Letter card game (great game, by the way, I recommend you buy a copy) based on an in-joke that goes back 20+ years.
Printing custom cards can be a tricky thing. The images below are appropriately-sized for printing as 2.5″x3.5″ cards if you want to download them individually. I also have a quick-and-dirty printable PDF of all 8(16) cards here.